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Selected Publications

Cook IA, Hunter AM, Gilmer WS, Iosifescu D, Zisook S, Burgoyne KS, Howland RH, Trivedi MH, Jain R, Greenwald S, Leuchter AF: Biomarkers for predicting likelihood and speed of achieving sustained remission in Major Depression: a BRITE-MD report. (in submission)

Caudill M, Hunter AM, Greenwald S, Cook IA, Leuchter AF: The Antidepressant Treatment Response (ATR) index and reboxetine treatment outcome in Major Depressive Disorder. (in submission)

McGrath P, Nunes EV, Hasin D, Stewart JW, Chen Y, Jiang H, Thase M, Kornstein SG, Leuchter AF, Davis L, Rush AJ: Recovery from Major Depression in patients with concurrent alcohol use disorders: a STAR*D report. (in submission)

Korb AS, Hunter AM, Cook IA, Leuchter AF: Rostral anterior cingulate cortex activity and early symptom improvement during treatment for major depressive disorder. (in submission)

Cook IA, Hunter AM, Farahbod H, Korb AS, Leuchter AF: Focused EEG array systems for clinical monitoring in depression. (in submission)

Hunter AM, Cook IA, Greenwald S, Tran ML, Miyamoto KN, Leuchter AF: The Antidepressant Treatment Response (ATR) index and treatment outcomes in a placebo-controlled trial of fluoxetine. (in submission)

Hunter AM, Bordelon YM, Cook IA, Leuchter, AF: Quantitative electroencephalographic measures in Huntington’s Disease: a pilot study. PLoS Currents: Huntington Disease (in press)

Muthen B, Asparouhov T, Hunter AM, Leuchter AF: Growth mixture modeling with possibly non-ignorable dropout: alternative analyses of the STAR*D antidepressant trial. Psychological Methods (in press).

Hunter AM, Cook IA, Leuchter AF: Impact of antidepressant treatment history on clinical outcomes in placebo and medication treatment of Major Depression. Journal of Clinical Psychopharmacology (in press)

Leuchter AF, Cook IA, Hamilton SP, Narr KL, Toga A, Hunter AM, Faull K, Whitelegge J, Andrew AM, Loo J, Way B, Nelson SF, Horvath S, Lebowitz BD: Biomarkers to predict antidepressant treatment response. Current Psychiatry Reports 12:553–562, 2010.

Warden D, Trivedi MH, Wisniewski SR, Friedman ES, Leuchter AF, Kornstein S, Kurian B, Fava M, Zisook S, Miyahara S, Rush AJ: Early adverse events and attrition in SSRI treatment: a suicide methodology study (SAMS) report. Journal of Clinical Psychopharmacology 30:259-66, 2010.

Hunter AM, Leuchter AF, Cook IA, Abrams M: Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment. Acta Psychiatr Scand 2010 Apr 8. [Epub ahead of print]

Kobak KA, Leuchter AF, DeBrota D, Engelhardt N, Williams JBW, Cook IA, Leon AC, Alpert JE: Site vs. centralized raters in a clinical depression trial: impact on patient selection and placebo response. Journal of Clinical Psychopharmacology 2010; 30(2):193-197

Farahbod H, Cook IA, Korb AS, Hunter AM, Leuchter AF: Amygdala lateralization at rest and during viewing of neutral faces in major depressive disorder using low-resolution brain electromagnetic tomography. Clin EEG Neurosci 2010; 41(1):19-23

Results from BRITE-MD Study

Hunter AM, Muthen BO, Cook IA, Leuchter AF. Antidepressant response trajectories and quantitative electroencephalography (QEEG) biomarkers in Major Depressive Disorder. J Psychiatr Res 2009; 44(2):90-98

Leuchter AF, Cook IA, Hunter AM, Korb AS. A new paradigm for the prediction of Antidepressant Treatment Response. Dialogues in clinical Neuroscience 2009; 11(4):435-46

Hunter AM, Leuchter AF, Cook IA, Abrams M. Brain Functional Changes (QEEG Cordance) and Worsening Suicidal Ideation and Mood Symptoms during antidepressant Treatment. Acta Psychiatr Scand (in press)

Farabod H, Cook IA, Korb AS, Hunter AM, Leuchter AF. Early amygdala processing of emotional stimuli in Major Depressive disorder. (in submission)

Warden D, Trivedi MH, wisniewski SR, Friedman ES, Leuchter AF, Kornstein s, Kurian B, Fava M, Zisook S, Miyahara S, Rush AJ. Early adverse events and attrition in SSRI treatment: a suicide methodology study (SAMS) report. (in submission)

Kobak KA, Leuchter AF, DeBrota D, Engelhardt N, Williams JBW, Cook IA, Leon AC, Alpert JE. Site vs. centralized raters in a clinical depression trial: impact on patient selection and placebo response. (in submission)

Cook IA, Hunter AM, Farahbod H, Korb AS, Leuchter AF. Focused EEG array systems for clinical monitoring in depression. (in submission)

Farahbod H, Cook IA, Hunter AM, Korb AS, Leuchter AF. Fusiform gyrus activity at rest and during viewing of facial images in Major Depressive Disorder. (in submission)

Korb AS, Hunter AM, Cook IA, Leuchter AF. Rostral Anterior Cingulate Cortex Activity and Early Symptom Improvement During Treatment for Major Depressive Disorder. (in submission)

Farahbod H, Cook IA, Hunter AM, Korb AS, Leuchter AF. Time-dependent processing of emotional stimuli in the amygdala in Major Depressive Disorder. (in submission)

Leuchter AF, Husain MM, Cook IA, Trivedi MH, Wisniewski SR, Gilmer W, Luther JF, Fava M, Rush AJ. Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D report. Psychological Medicine 40(2): 239-252, 2010.

Kalechstein Ad, De La Garza R, Newton TF, Green MF, Cook IA, Leuchter AF. Quantitative EEG abnormalities are associated with memory impairment in recently abstinent methamphetamine-dependent individuals. J Neuropsychiatry Clin Neurosci 21: 254-258, 2009.

Korb AS, Hunter AM, Cook IA, Leuchter AF. Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in Major Depression. Clinical Neurophysiology 120(7): 1313-9, 2009.

Cook IA, Hunter AM, Abrams M, Siegman B, Leuchter AF. Midline and right frontal brain function as a physiologic biomarker of remission in major depression. Psychiatry Research: Neuroimaging 174(2): 152-7, 2009.

Leuchter AF, McCracken JT, Hunter AM, Cook IA, Alpert JE. MAO-A and COMT functional poymorphisms and the placebo response in Major Depressive Disorder. Journal of Clinical Psychopharmacology 29(4): 372-377, 2009.

Leuchter AF, Cook IA, Gilmer WS, Marangell LB, Burgoyne KS, Howland RH, Trivedi MH, Zisook S, Jain R, Fava M, Iosifescu D, Greenwald S. Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in Major Depressive Disorder. Psychiatry Research 169: 132-138, 2009.

Leuchter AF, Cook IA, Marangell LB, Glimter WS, Burgoyne KS, Howland RH, Trivedi MH, Zisook S, Jain R, McCracken JT, Fava M, Iosifescu D, Greenwald S. Comparative effectiveness of biomarkers and clinical indicators for predicting outcomes of SSRI treatment in Major Depressive Disorder: results of the BRITE-MD study. Psychiatry Research 169: 124-131, 2009.

Hunter AM, Leuchter AF, Cook IA, Abrams M, Siegman BE, Furst DE, Chappell AS. Brain functional changes and duloxetine treatment response in fibromyalgia. Pain Medicine 2009 Apr 22 [Epub ahead of print]

Leuchter AF, Cook IA, Hunter AM, Korb AS. Use of clinical neurophysiology for the selection of medication in the treatment of Major Depressive Disorder: the state of the evidence. Clinical EEG & Neuroscience 40(2): 78-83, 2009.

Hunter AM, Leuchter AF, Cook IA, Abrams M, Siegman BE, Furst DE, Chappell AS. Brain functional changes and duloxetine treatment response in fibromyalgia. Pain Medicine 10(4): 730-8, 2009.

Leuchter AF, Lesser IM, Trivedi MH, Rush AJ, Morris DW, Warden D, Fava M, Wisniewski SR, Luther JF, Perales M, Gaynes BN, Stewart JW. An open pilor study of the combination of escitalopram and bupropion-SR for outpatients with Major Depressive Disorder. Journal of Psychiatric Practice 14(5): 271-80, 2008.

Korb AS, Cook IA, Hunter AM, Leuchter AF. Brain electrical source differences between depressed subjects and healthy controls. Brain Toppography 21(2): 138-46, 2008.

Hunter AM, Ravikumar S, Cook IA, Leuchter Af. Brain functional changes during placebo lead-in and changes in specific symptoms during pharmacotherapy for major depression. Acta Psychiatr Scand 119(4): 266-273, 2008.

Leuchter AF, Cook IA, DeBrota DJ, Hunter AM, Potter WZ, McGrouther CC, Morgan ML, Abrams M, Siegman B. Changes in brain function during administration of venlafaxine or placebo to normal subjects. Clinical EEG & Neuroscience 39(4): 175-81, 2008.

Cook IA, Pajot SK, Leuchter AF. Ancient architectural resonance patterns and regional brain activity. Time and Mind 1(1): 95-107, 2008.

Fava M, Rush AJ, Alpert JE, Balasubramani GK, Wisniewski SR, Carmin CN, Biggs MM, Zisook S, Leuchter AF, Howland R, Warden D, Trivedi MH. Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. American Journal of Psychiatry 10: 1176, 2008.

Morgan ML, Cook IA, Rapkin AJ, Leuchter AF. Neurophysiologic changes during estrogen augmentation in perimenopausal depression. Maturitas 56(1): 54-60, 2007.

Lesser IM, Leuchter AF, Trivedi MH, Davis LL, Wisniewski SR, Balasubramani GK, Fava M, Rush AJ. Insured and non-insured depressed outpatients: how do they compare? Annals of Clinical Psychiatry 19(2):73-82, 2007.

Hunter AM, Cook IA, Leuchter AF. The Promise of the Quantitative Electroencephalogram as a Predictor of Antidepressant Treatment Outcomes in Major Depressive Disorder. Psychiatr Clin North Am 30(1):105-124, 2007.

Shapiro D, Cook IA, Davydov DM, Ottaviani C, Leuchter AF, Abrams M. Yoga as a Complementary Treatment of Depression: Effects of Traits and Moods on Treatment Outcome. Evidence Based Complementary and Alternative Medicine 4(4): 493-502, 2007.

Cook IA, Bookheimer SY, Mickes L, Leuchter AF, Kumar A. Aging and brain activation with working memory tasks: an fMRI study of connectivity. International Journal of Geriatric Psychiatry. 22(4):332-42, 2007.

Claassen CA, Trivedi MH, Rush JA, Husain MM, Zisook S, Young E, Leuchter AF, Wisniewski SR, Balasubramani GK, Alpert J. Clinical differences among depressed patients with and without a history of suicde attempts: findings from the STAR*D trial. J Affective Disorders 97:77-84, 2007.