Personalized Response Indicators of SSRI Effectiveness in Major Depression (PRISE-MD)

Ian A. Cook, M.D., Principal Investigator
Support provided by National Institutes of Mental Health
Grant # here

Currently Recruiting

     Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients worldwide, yet treatments chosen under current best practices frequently do not lead to recovery with the initial medication tried; this yields prolonged symptomatic suffering, functional disability, increased risk of relapse, and risk that individuals will abandon treatment efforts altogether.  Better outcomes might be possible if a biomarker could guide clinicians in selecting among treatments. This project will examine biomarker predictions of outcome based on quantitative electroencephalographic (QEEG) features that change during a week of exposure to an SSRI antidepressant medication; by allowing clinicians to use treatments more effectively, the use of physiologic biomarker information for guidance could have a significant impact on the management of MDD.