Evaluation of Low Emission NeoSync EEG Synchronized TMS Technology For the Treatment of Major Depressive Disorder

Primary Investigator: Ian A. Cook, MD: The purpose of this research study is to examine the effects of Neosync sTMS therapy in depression for people who have failed at least one antidepressant trial. This study is examining the effects on mood, life functioning and satisfaction, brain chemistry, and brain activity during treatment. The study examines these items in individuals who have depression, who have tried other forms of treatment, and who are seeking new treatment. The study will enroll about 30 subjects at UCLA, and each may receive active treatment or sham treatment during his/her participation. During the 10 week study, the subject will be asked to come in for 30 study visits over six weeks and one study visit at the 10th week. After an initial interview by a physician and a nurse, subjects who are eligible to participate will receive a psychiatric evaluation, a QEEG test to measure brain activity, and their TMS treatment. In addition, subjects will answer questions about their medical and psychiatric history and respond to a variety of psychological and quality of life questionnaires.