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Basic Neurobiology
How can we integrate multiple perspectives to learn more about the brain and the mind? At times we have looked at more fundamental aspects of brain function to expand what we know about how the brain works. In our efforts to understand more about what the electrical signals reflect, we have simultaneously measured electrical activity at the scalp and the patterns of blood flow within the brain (PET scanning); we have measured the activity of the brain in its resting state and when the mind is engaged in some task (a motor task like squeezing one's hand, or a cognitive task like remembering a series of objects); we have monitored brain function as psychoactive medications are administered, either orally or by intravenous infusion. Our work in this area led to the development of Cordance, a new QEEG measure that reflects cerebral energy utilization. Work with animal models has expanded our ability to relate electrical measurements at the scalp to electrical measurements within the brain, and to relate these, in turn, to observations about the animals' behavior.
current NIH grants R01 MH40705 (Dr. Leuchter, PI), K02 MH01165 (Dr. Leuchter, PI), K08 MH01483 (Dr. Cook, PI), support from NARSAD (Dr. Cook, PI) support from the Veterans Administration (Dr. Leuchter, PI), and foundation support (Dr. Holschneider, PI)
