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Substance Abuse and Addiction
How is brain function altered by addictive substances? how long do these changes last? are there differences between different but related compounds (for example, the stimulants cocaine, methamphetamine, dexamphetamine, nicotine)? can a medication that blocks the physiologic changes of an addictive drug be used in treatment for substance abuse? We have undertaken projects in which chemically-depedent subjects are studied naturalistically as they maintain their abstinence and at times when they have relapsed and are using again. Compounds with potential for blocking the "high" are being examined for their physiologic signatures.
NIH grants K08 DA00388 (Dr. Newton, PI) and support from the Veterans Administration
